Cell-type-specific And Shared EQTL fine-mapping • CASE

CASE is an R package designed for multi-trait fine-mapping analysis, with a particular focus on single-cell eQTL fine-mapping.

1. Installation

CASE can be installed from the Github Repo.

# Install the devtools package if you haven't already
# install.packages("devtools")

devtools::install_github("leaffur/CASE")

2. Quick Start

For an introductory overview, please refer to this vignette.

After loading the package with library(CASE), you can access simple examples and guidance using the ?CASE command in R.

This is an early version of CASE, and we welcome any feedback or suggestions for improvement.

3. Reference

Lin, C. et al. (2025). Leveraging cell-type specificity and similarity improves single-cell eQTL fine-mapping. bioRxiv. Link.